GHK-Cu Peptide for Skin and Hair — The Copper Peptide Encyclopedia

GHK-Cu is the most-studied copper peptide for skin regeneration and hair follicle stimulation. Available topically, via dermal microneedling, or compounded subcutaneously. NexLife's peptide therapy and hair health programs include GHK-Cu protocols.

The peptide

GHK-Cu is glycyl-L-histidyl-L-lysine bound to a copper ion. Discovered in 1973 by Loren Pickart as a serum factor that improved liver-tissue function in older rodents. Subsequently shown to stimulate dermal fibroblasts, upregulate collagen and elastin synthesis, and modulate wound healing.

Skin regeneration applications

Topical GHK-Cu (typically 0.05%–0.2% in serums or creams) reduces visible signs of photoaging, improves skin elasticity, and reduces fine line depth in controlled studies. Effective formulations require the copper to remain bound (some products separate; check formulation).

Hair regrowth applications

See GHK-Cu microneedle delivery in androgenetic alopecia. The peptide stimulates dermal papilla and prolongs anagen phase. Microneedle delivery dramatically improves transdermal penetration over topical-only.

Delivery routes

• Topical 0.1%–0.2% — daily for skin; daily with microneedling for hair
• Compounded subcutaneous — 1–2 mg 2× weekly, used in functional medicine

NexLife use

NexLife's peptide therapy and hair health programs include GHK-Cu protocols under physician oversight by Medical Director Adam Kennah, M.D..

Sources

• Pickart L, Margolina A — GHK-Cu peptide review — Cosmetics 2018
• Pyo HK et al., Tripeptide for hair growth — Int J Cosmet Sci
• Pickart L — Original 1973 discovery, J Invest Dermatol