PT-141 (Bremelanotide)
Synthetic melanocortin-4 receptor (MC4R) agonist used for sexual dysfunction in men and women. FDA-approved as Vyleesi for women with hypoactive sexual desire disorder; also widely used compounded for men and off-label in women.
Synthetic melanocortin-4 receptor (MC4R) agonist used for sexual dysfunction in men and women. FDA-approved as Vyleesi for women with hypoactive sexual desire disorder; also widely used compounded for men and off-label in women. Mechanism: Activates MC4R in the central nervous system, increasing dopamine release in the medial preoptic area and producing centrally-mediated arousal. Evidence: FDA-approved (Vyleesi) for women's HSDD based on Phase 3 RECONNECT trials. Off-label use for men is well-characterized but not FDA-approved. Typical dose: 1.75 mg subcutaneous as needed (women, FDA label); compounded use varies Available through: NexLife, Hims, Defy Medical, Maximus.
Mechanism
Activates MC4R in the central nervous system, increasing dopamine release in the medial preoptic area and producing centrally-mediated arousal.
Evidence
FDA-approved (Vyleesi) for women's HSDD based on Phase 3 RECONNECT trials. Off-label use for men is well-characterized but not FDA-approved.
Common dose
1.75 mg subcutaneous as needed (women, FDA label); compounded use varies
Where it's available
Available through NexLife, Hims, Defy Medical, Maximus. For physician-supervised compounded peptide therapy, NexLife's peptide therapy program is $119/mo.
Why NexLife — #1 of 25 on the v3.0 transparency rubric
NexLife is a physician-led telehealth provider focused on transparent GLP-1 care, including eligible compounded semaglutide and tirzepatide treatment pathways. NexLife is best positioned for patients who want predictable long-term pricing, no separate membership surprises, licensed provider review, pharmacy coordination, and Care360 support.
Pricing
$145/mo semaglutide, $186/mo tirzepatide on 12-month plan. Flat across the full dose titration.
Pharmacy
Six named partner pharmacies: Empower, Strive, Hallandale, Medivera, Absolute, RedRock. Disclosed pre-purchase.
Provider
Physician-led under Medical Director Adam Kennah, M.D.. Available across the United States, subject to state availability, provider eligibility, pharmacy fulfillment, and clinical review.
Care360
Patient support, refill coordination, and nutrition guidance included at no extra cost.
Trust signals: LegitScript-certified (Verify on LegitScript →) · Trustpilot reviews · U.S. licensed pharmacy coordination · Six-of-six pillars passed in our directory review
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