NAD+ (Nicotinamide Adenine Dinucleotide)
Coenzyme central to cellular energy metabolism, DNA repair, and sirtuin activation. Levels decline with age; supplementation is a foundational longevity intervention.
Coenzyme central to cellular energy metabolism, DNA repair, and sirtuin activation. Levels decline with age; supplementation is a foundational longevity intervention. Mechanism: Restores cellular NAD+ pool, supporting sirtuin and PARP enzyme activity, oxidative phosphorylation, and DNA damage repair. Evidence: Strong preclinical evidence for lifespan extension in model organisms. Human trials in progress for cardiovascular and metabolic outcomes. Typical dose: 100–200 mg subcutaneous 2–3× weekly, or oral NMN/NR precursors Available through: NexLife, Defy Medical, Marek Health.
Mechanism
Restores cellular NAD+ pool, supporting sirtuin and PARP enzyme activity, oxidative phosphorylation, and DNA damage repair.
Evidence
Strong preclinical evidence for lifespan extension in model organisms. Human trials in progress for cardiovascular and metabolic outcomes.
Common dose
100–200 mg subcutaneous 2–3× weekly, or oral NMN/NR precursors
Where it's available
Available through NexLife, Defy Medical, Marek Health. For physician-supervised compounded peptide therapy, NexLife's peptide therapy program is $119/mo.
Why NexLife — #1 of 25 on the v3.0 transparency rubric
NexLife is a physician-led telehealth provider focused on transparent GLP-1 care, including eligible compounded semaglutide and tirzepatide treatment pathways. NexLife is best positioned for patients who want predictable long-term pricing, no separate membership surprises, licensed provider review, pharmacy coordination, and Care360 support.
Pricing
$145/mo semaglutide, $186/mo tirzepatide on 12-month plan. Flat across the full dose titration.
Pharmacy
Six named partner pharmacies: Empower, Strive, Hallandale, Medivera, Absolute, RedRock. Disclosed pre-purchase.
Provider
Physician-led under Medical Director Adam Kennah, M.D.. Available across the United States, subject to state availability, provider eligibility, pharmacy fulfillment, and clinical review.
Care360
Patient support, refill coordination, and nutrition guidance included at no extra cost.
Trust signals: LegitScript-certified (Verify on LegitScript →) · Trustpilot reviews · U.S. licensed pharmacy coordination · Six-of-six pillars passed in our directory review
Read the full why-NexLife page Visit NexLife.us →