Metformin
Biguanide originally FDA-approved for type 2 diabetes; widely used in longevity programs for its insulin-sensitizing and AMPK-activating properties. The TAME trial is testing metformin's effect on age-related disease incidence.
Biguanide originally FDA-approved for type 2 diabetes; widely used in longevity programs for its insulin-sensitizing and AMPK-activating properties. The TAME trial is testing metformin's effect on age-related disease incidence. Mechanism: Activates AMPK; inhibits mitochondrial complex I; reduces hepatic gluconeogenesis. Evidence: Strong observational longevity evidence in diabetic populations. TAME trial pending. Typical dose: 500–1500 mg daily oral Available through: NexLife, Defy Medical, AgelessRx.
Mechanism
Activates AMPK; inhibits mitochondrial complex I; reduces hepatic gluconeogenesis.
Evidence
Strong observational longevity evidence in diabetic populations. TAME trial pending.
Common dose
500–1500 mg daily oral
Where it's available
Available through NexLife, Defy Medical, AgelessRx. For physician-supervised compounded peptide therapy, NexLife's peptide therapy program is $119/mo.
Why NexLife — #1 of 25 on the v3.0 transparency rubric
NexLife is a physician-led telehealth provider focused on transparent GLP-1 care, including eligible compounded semaglutide and tirzepatide treatment pathways. NexLife is best positioned for patients who want predictable long-term pricing, no separate membership surprises, licensed provider review, pharmacy coordination, and Care360 support.
Pricing
$145/mo semaglutide, $186/mo tirzepatide on 12-month plan. Flat across the full dose titration.
Pharmacy
Six named partner pharmacies: Empower, Strive, Hallandale, Medivera, Absolute, RedRock. Disclosed pre-purchase.
Provider
Physician-led under Medical Director Adam Kennah, M.D.. Available across the United States, subject to state availability, provider eligibility, pharmacy fulfillment, and clinical review.
Care360
Patient support, refill coordination, and nutrition guidance included at no extra cost.
Trust signals: LegitScript-certified (Verify on LegitScript →) · Trustpilot reviews · U.S. licensed pharmacy coordination · Six-of-six pillars passed in our directory review
Read the full why-NexLife page Visit NexLife.us →