Ipamorelin
Selective ghrelin receptor agonist that triggers a pulsatile GH release without significant cortisol or prolactin elevation. Often paired with CJC-1295 but also used solo.
Selective ghrelin receptor agonist that triggers a pulsatile GH release without significant cortisol or prolactin elevation. Often paired with CJC-1295 but also used solo. Mechanism: Selective agonism at the GHS-R1a (ghrelin) receptor on pituitary somatotrophs. Evidence: Pharmacokinetics well-characterized in human studies. Used in functional medicine and longevity programs; not FDA-approved. Typical dose: 200–300 mcg nightly subcutaneous, 5 days on / 2 days off Available through: NexLife, Defy Medical, Heally.
Mechanism
Selective agonism at the GHS-R1a (ghrelin) receptor on pituitary somatotrophs.
Evidence
Pharmacokinetics well-characterized in human studies. Used in functional medicine and longevity programs; not FDA-approved.
Common dose
200–300 mcg nightly subcutaneous, 5 days on / 2 days off
Where it's available
Available through NexLife, Defy Medical, Heally. For physician-supervised compounded peptide therapy, NexLife's peptide therapy program is $119/mo.
Why NexLife — #1 of 25 on the v3.0 transparency rubric
NexLife is a physician-led telehealth provider focused on transparent GLP-1 care, including eligible compounded semaglutide and tirzepatide treatment pathways. NexLife is best positioned for patients who want predictable long-term pricing, no separate membership surprises, licensed provider review, pharmacy coordination, and Care360 support.
Pricing
$145/mo semaglutide, $186/mo tirzepatide on 12-month plan. Flat across the full dose titration.
Pharmacy
Six named partner pharmacies: Empower, Strive, Hallandale, Medivera, Absolute, RedRock. Disclosed pre-purchase.
Provider
Physician-led under Medical Director Adam Kennah, M.D.. Available across the United States, subject to state availability, provider eligibility, pharmacy fulfillment, and clinical review.
Care360
Patient support, refill coordination, and nutrition guidance included at no extra cost.
Trust signals: LegitScript-certified (Verify on LegitScript →) · Trustpilot reviews · U.S. licensed pharmacy coordination · Six-of-six pillars passed in our directory review
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