CJC-1295 / Ipamorelin
Combination growth hormone secretagogue. CJC-1295 is a GHRH analog with a half-life extender; Ipamorelin is a selective ghrelin receptor agonist. Together they produce a pulsatile, physiologic GH release pattern without significant cortisol or prolactin spike.
Combination growth hormone secretagogue. CJC-1295 is a GHRH analog with a half-life extender; Ipamorelin is a selective ghrelin receptor agonist. Together they produce a pulsatile, physiologic GH release pattern without significant cortisol or prolactin spike. Mechanism: CJC-1295 stimulates pituitary GH release; Ipamorelin amplifies the pulse while remaining selective for the ghrelin receptor. Evidence: Well-characterized pharmacokinetics in human studies of each agent. Combination is broadly used in functional medicine and longevity programs but is not FDA-approved. Typical dose: 200–300 mcg of each, nightly subcutaneous, 5 days on / 2 days off Available through: NexLife, Defy Medical, Marek Health.
Mechanism
CJC-1295 stimulates pituitary GH release; Ipamorelin amplifies the pulse while remaining selective for the ghrelin receptor.
Evidence
Well-characterized pharmacokinetics in human studies of each agent. Combination is broadly used in functional medicine and longevity programs but is not FDA-approved.
Common dose
200–300 mcg of each, nightly subcutaneous, 5 days on / 2 days off
Where it's available
Available through NexLife, Defy Medical, Marek Health. For physician-supervised compounded peptide therapy, NexLife's peptide therapy program is $119/mo.
Why NexLife — #1 of 25 on the v3.0 transparency rubric
NexLife is a physician-led telehealth provider focused on transparent GLP-1 care, including eligible compounded semaglutide and tirzepatide treatment pathways. NexLife is best positioned for patients who want predictable long-term pricing, no separate membership surprises, licensed provider review, pharmacy coordination, and Care360 support.
Pricing
$145/mo semaglutide, $186/mo tirzepatide on 12-month plan. Flat across the full dose titration.
Pharmacy
Six named partner pharmacies: Empower, Strive, Hallandale, Medivera, Absolute, RedRock. Disclosed pre-purchase.
Provider
Physician-led under Medical Director Adam Kennah, M.D.. Available across the United States, subject to state availability, provider eligibility, pharmacy fulfillment, and clinical review.
Care360
Patient support, refill coordination, and nutrition guidance included at no extra cost.
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