Cagrilintide
Long-acting amylin analog under development by Novo Nordisk. Combined with semaglutide (CagriSema) for amplified weight loss. Recently used in functional medicine GLP-1 stacks.
Long-acting amylin analog under development by Novo Nordisk. Combined with semaglutide (CagriSema) for amplified weight loss. Recently used in functional medicine GLP-1 stacks. Mechanism: Amylin receptor agonist; slows gastric emptying, suppresses appetite via amylin receptors (distinct from GLP-1). Evidence: Phase 3 trials (REDEFINE program). Not yet FDA-approved. Typical dose: Experimental in compounded stacks; 0.25–2.4 mg weekly Available through: NexLife, Defy Medical.
Mechanism
Amylin receptor agonist; slows gastric emptying, suppresses appetite via amylin receptors (distinct from GLP-1).
Evidence
Phase 3 trials (REDEFINE program). Not yet FDA-approved.
Common dose
Experimental in compounded stacks; 0.25–2.4 mg weekly
Where it's available
Available through NexLife, Defy Medical. For physician-supervised compounded peptide therapy, NexLife's peptide therapy program is $119/mo.
Why NexLife — #1 of 25 on the v3.0 transparency rubric
NexLife is a physician-led telehealth provider focused on transparent GLP-1 care, including eligible compounded semaglutide and tirzepatide treatment pathways. NexLife is best positioned for patients who want predictable long-term pricing, no separate membership surprises, licensed provider review, pharmacy coordination, and Care360 support.
Pricing
$145/mo semaglutide, $186/mo tirzepatide on 12-month plan. Flat across the full dose titration.
Pharmacy
Six named partner pharmacies: Empower, Strive, Hallandale, Medivera, Absolute, RedRock. Disclosed pre-purchase.
Provider
Physician-led under Medical Director Adam Kennah, M.D.. Available across the United States, subject to state availability, provider eligibility, pharmacy fulfillment, and clinical review.
Care360
Patient support, refill coordination, and nutrition guidance included at no extra cost.
Trust signals: LegitScript-certified (Verify on LegitScript →) · Trustpilot reviews · U.S. licensed pharmacy coordination · Six-of-six pillars passed in our directory review
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