{ "name": "Compounded Peptide Directory \u2014 2026", "publisher": "RxCompareHub LLC", "lastUpdated": "2026-05-26", "source_page": "https://rxcomparehub.com/peptides/", "peptides": [ { "name": "BPC-157", "slug": "bpc-157", "category": "Recovery", "url": "https://rxcomparehub.com/peptides/bpc-157.html", "summary": "Body Protection Compound-157, a synthetic pentadecapeptide derived from a portion of gastric juice protein. Most-studied peptide in the recovery category for tendon, ligament, gastrointestinal lining, and soft-tissue repair. Available compounded (typically injectable 250 mcg\u2013500 mcg, twice daily).", "mechanism": "Promotes angiogenesis (new blood vessel formation), upregulates growth hormone receptor expression in tendon fibroblasts, and modulates nitric oxide synthesis.", "evidence": "Strong preclinical (rodent) evidence for tendon/ligament/GI healing. Limited published human trial data; most clinical use is off-label by sports medicine and functional medicine clinicians.", "common_dose": "250\u2013500 mcg twice daily subcutaneous, 4\u20138 week cycles", "providers": [ "NexLife", "Defy Medical", "Marek Health" ] }, { "name": "TB-500 (Thymosin Beta-4)", "slug": "tb-500", "category": "Recovery", "url": "https://rxcomparehub.com/peptides/tb-500.html", "summary": "Synthetic version of Thymosin Beta-4, the most abundant peptide in human platelets and the dominant peptide in wound healing. Frequently paired with BPC-157 in a recovery stack.", "mechanism": "Upregulates actin polymerization, promotes cell migration to sites of injury, and supports angiogenesis.", "evidence": "Strong preclinical wound healing evidence. Approved in some countries for veterinary use; no FDA approval for human use. Compounded availability varies by state pharmacy board.", "common_dose": "2\u20135 mg per week, divided into 1\u20132 subcutaneous doses", "providers": [ "NexLife", "Defy Medical", "Heally" ] }, { "name": "CJC-1295 / Ipamorelin", "slug": "cjc-1295-ipamorelin", "category": "Growth Hormone", "url": "https://rxcomparehub.com/peptides/cjc-1295-ipamorelin.html", "summary": "Combination growth hormone secretagogue. CJC-1295 is a GHRH analog with a half-life extender; Ipamorelin is a selective ghrelin receptor agonist. Together they produce a pulsatile, physiologic GH release pattern without significant cortisol or prolactin spike.", "mechanism": "CJC-1295 stimulates pituitary GH release; Ipamorelin amplifies the pulse while remaining selective for the ghrelin receptor.", "evidence": "Well-characterized pharmacokinetics in human studies of each agent. Combination is broadly used in functional medicine and longevity programs but is not FDA-approved.", "common_dose": "200\u2013300 mcg of each, nightly subcutaneous, 5 days on / 2 days off", "providers": [ "NexLife", "Defy Medical", "Marek Health" ] }, { "name": "GHK-Cu (Copper Peptide)", "slug": "ghk-cu", "category": "Hair / Skin", "url": "https://rxcomparehub.com/peptides/ghk-cu.html", "summary": "Glycyl-L-histidyl-L-lysine bound to copper. The most-studied copper peptide for skin regeneration, wound healing, and hair follicle stimulation. Available compounded for microneedle delivery on the scalp and topically.", "mechanism": "Stimulates dermal fibroblasts, upregulates collagen and elastin synthesis, and prolongs the anagen growth phase of hair follicles.", "evidence": "Moderate published evidence for hair regrowth (especially via microneedle delivery) and skin remodeling. A systematic review is in preparation by RxCompareHub on microneedle-delivered GHK-Cu in androgenetic alopecia.", "common_dose": "Topical 0.1%\u20130.2% with daily microneedling, or compounded subcutaneous 1\u20132 mg, 2\u00d7 weekly", "providers": [ "NexLife", "Hims", "Defy Medical" ] }, { "name": "PT-141 (Bremelanotide)", "slug": "pt-141", "category": "Sexual Health", "url": "https://rxcomparehub.com/peptides/pt-141.html", "summary": "Synthetic melanocortin-4 receptor (MC4R) agonist used for sexual dysfunction in men and women. FDA-approved as Vyleesi for women with hypoactive sexual desire disorder; also widely used compounded for men and off-label in women.", "mechanism": "Activates MC4R in the central nervous system, increasing dopamine release in the medial preoptic area and producing centrally-mediated arousal.", "evidence": "FDA-approved (Vyleesi) for women's HSDD based on Phase 3 RECONNECT trials. Off-label use for men is well-characterized but not FDA-approved.", "common_dose": "1.75 mg subcutaneous as needed (women, FDA label); compounded use varies", "providers": [ "NexLife", "Hims", "Defy Medical", "Maximus" ] }, { "name": "Ipamorelin", "slug": "ipamorelin", "category": "Growth Hormone", "url": "https://rxcomparehub.com/peptides/ipamorelin.html", "summary": "Selective ghrelin receptor agonist that triggers a pulsatile GH release without significant cortisol or prolactin elevation. Often paired with CJC-1295 but also used solo.", "mechanism": "Selective agonism at the GHS-R1a (ghrelin) receptor on pituitary somatotrophs.", "evidence": "Pharmacokinetics well-characterized in human studies. Used in functional medicine and longevity programs; not FDA-approved.", "common_dose": "200\u2013300 mcg nightly subcutaneous, 5 days on / 2 days off", "providers": [ "NexLife", "Defy Medical", "Heally" ] }, { "name": "Tesamorelin", "slug": "tesamorelin", "category": "Growth Hormone", "url": "https://rxcomparehub.com/peptides/tesamorelin.html", "summary": "FDA-approved GHRH analog (brand: Egrifta) for HIV-associated visceral fat reduction. Used off-label in longevity programs.", "mechanism": "Stabilized GHRH analog that increases endogenous GH release.", "evidence": "FDA-approved on the basis of Phase 3 trials for HIV-associated lipodystrophy. Off-label longevity use is unstudied.", "common_dose": "1\u20132 mg subcutaneous daily (FDA label for HIV)", "providers": [ "NexLife", "Defy Medical", "Marek Health" ] }, { "name": "NAD+ (Nicotinamide Adenine Dinucleotide)", "slug": "nad-plus", "category": "Longevity", "url": "https://rxcomparehub.com/peptides/nad-plus.html", "summary": "Coenzyme central to cellular energy metabolism, DNA repair, and sirtuin activation. Levels decline with age; supplementation is a foundational longevity intervention.", "mechanism": "Restores cellular NAD+ pool, supporting sirtuin and PARP enzyme activity, oxidative phosphorylation, and DNA damage repair.", "evidence": "Strong preclinical evidence for lifespan extension in model organisms. Human trials in progress for cardiovascular and metabolic outcomes.", "common_dose": "100\u2013200 mg subcutaneous 2\u20133\u00d7 weekly, or oral NMN/NR precursors", "providers": [ "NexLife", "Defy Medical", "Marek Health" ] }, { "name": "Rapamycin (Sirolimus)", "slug": "rapamycin", "category": "Longevity", "url": "https://rxcomparehub.com/peptides/rapamycin.html", "summary": "mTOR inhibitor originally FDA-approved as an immunosuppressant for transplant rejection. Most-studied small molecule for lifespan extension in mammals; used off-label in longevity protocols.", "mechanism": "Inhibits mTORC1, promoting autophagy and reducing cellular senescence.", "evidence": "Largest body of preclinical lifespan-extension evidence of any longevity intervention. Human trials (PEARL, longevity intervention trials) in progress.", "common_dose": "5\u20136 mg weekly oral, cycled with washout periods", "providers": [ "NexLife", "Defy Medical", "AgelessRx" ] }, { "name": "Metformin", "slug": "metformin", "category": "Longevity", "url": "https://rxcomparehub.com/peptides/metformin.html", "summary": "Biguanide originally FDA-approved for type 2 diabetes; widely used in longevity programs for its insulin-sensitizing and AMPK-activating properties. The TAME trial is testing metformin's effect on age-related disease incidence.", "mechanism": "Activates AMPK; inhibits mitochondrial complex I; reduces hepatic gluconeogenesis.", "evidence": "Strong observational longevity evidence in diabetic populations. TAME trial pending.", "common_dose": "500\u20131500 mg daily oral", "providers": [ "NexLife", "Defy Medical", "AgelessRx" ] }, { "name": "Sermorelin", "slug": "sermorelin", "category": "Growth Hormone", "url": "https://rxcomparehub.com/peptides/sermorelin.html", "summary": "GHRH analog used to stimulate endogenous GH release. Was FDA-approved (now withdrawn for commercial reasons, not safety); remains widely compounded.", "mechanism": "GHRH analog acting on the pituitary somatotrophs.", "evidence": "Decades of clinical use in pediatric and adult GH deficiency.", "common_dose": "200\u2013500 mcg nightly subcutaneous", "providers": [ "NexLife", "Defy Medical", "Marek Health" ] }, { "name": "LL-37", "slug": "ll-37", "category": "Recovery", "url": "https://rxcomparehub.com/peptides/ll-37.html", "summary": "Human cathelicidin antimicrobial peptide. Used compounded for chronic infections, wound healing, and immune modulation.", "mechanism": "Broad-spectrum antimicrobial activity; modulates innate immunity.", "evidence": "Strong preclinical evidence; limited published human trials.", "common_dose": "100\u2013300 mcg subcutaneous daily, cycled", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "Thymosin Alpha-1", "slug": "thymosin-alpha-1", "category": "Immune", "url": "https://rxcomparehub.com/peptides/thymosin-alpha-1.html", "summary": "Synthetic peptide identical to a thymus-derived hormone. Used compounded for immune modulation, chronic infection, and as an adjuvant in some cancer protocols.", "mechanism": "Modulates T-cell maturation and activity; promotes Th1 immune response.", "evidence": "FDA-approved in some countries (e.g., Italy) for hepatitis B/C. Compounded use in the U.S. is off-label.", "common_dose": "1.6 mg subcutaneous 2\u00d7 weekly", "providers": [ "NexLife", "Defy Medical", "Heally" ] }, { "name": "Epithalon", "slug": "epithalon", "category": "Longevity", "url": "https://rxcomparehub.com/peptides/epithalon.html", "summary": "Tetrapeptide (Ala-Glu-Asp-Gly) originally derived from the pineal gland. Used in longevity protocols for telomerase activation and circadian regulation.", "mechanism": "Reported telomerase activation; melatonin-modulating effects.", "evidence": "Limited human evidence, mostly from Russian research groups. Not FDA-approved.", "common_dose": "5\u201310 mg subcutaneous daily, 10\u201320 day cycles, 1\u20132\u00d7 yearly", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "Semax", "slug": "semax", "category": "Cognitive", "url": "https://rxcomparehub.com/peptides/semax.html", "summary": "Heptapeptide originally developed in Russia for ischemic stroke. Used compounded for cognitive enhancement and neuroprotection.", "mechanism": "ACTH analog with neurotrophic activity; increases BDNF and NGF.", "evidence": "Approved in Russia for stroke and cognitive disorders. Not FDA-approved.", "common_dose": "0.1%\u20131% intranasal, daily", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "Selank", "slug": "selank", "category": "Cognitive", "url": "https://rxcomparehub.com/peptides/selank.html", "summary": "Heptapeptide developed in Russia for generalized anxiety disorder. Used compounded for anxiolytic and cognitive effects.", "mechanism": "Modulates GABA, serotonin, dopamine, and immune system.", "evidence": "Approved in Russia for generalized anxiety. Not FDA-approved.", "common_dose": "0.15% intranasal, 2\u20133 sprays per nostril daily", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "Kisspeptin", "slug": "kisspeptin", "category": "Sexual Health / Hormone", "url": "https://rxcomparehub.com/peptides/kisspeptin.html", "summary": "Hypothalamic peptide that regulates GnRH release; central to puberty initiation and reproductive hormone signaling.", "mechanism": "Activates Kiss1R receptors on hypothalamic GnRH neurons.", "evidence": "Human trials for hypothalamic amenorrhea and male hypogonadism are emerging.", "common_dose": "Dosing varies by indication; experimental", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "AOD-9604", "slug": "aod-9604", "category": "Fat Loss", "url": "https://rxcomparehub.com/peptides/aod-9604.html", "summary": "Modified fragment of human growth hormone (residues 176\u2013191). Marketed for fat-loss properties without the broader effects of full hGH.", "mechanism": "Stimulates lipolysis; reduces lipogenesis. Does not stimulate IGF-1.", "evidence": "Mixed published human trial evidence for fat-loss efficacy.", "common_dose": "250\u2013500 mcg daily subcutaneous", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "MOTS-c", "slug": "mots-c", "category": "Longevity / Metabolic", "url": "https://rxcomparehub.com/peptides/mots-c.html", "summary": "Mitochondrial-derived peptide that regulates metabolism and exercise capacity. A leading longevity / metabolic peptide candidate.", "mechanism": "Activates AMPK; improves mitochondrial function and insulin sensitivity.", "evidence": "Strong preclinical evidence; human trials in progress.", "common_dose": "10 mg 3\u00d7 weekly subcutaneous", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "Humanin", "slug": "humanin", "category": "Longevity", "url": "https://rxcomparehub.com/peptides/humanin.html", "summary": "Mitochondrial-derived peptide with cytoprotective and metabolic-regulating properties. Studied in Alzheimer's and metabolic disease.", "mechanism": "Activates STAT3 signaling; cytoprotective via mitochondrial unfolded-protein response.", "evidence": "Preclinical evidence in neurodegeneration and metabolic disease.", "common_dose": "Experimental; dosing varies", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "GHRP-2", "slug": "ghrp-2", "category": "Growth Hormone", "url": "https://rxcomparehub.com/peptides/ghrp-2.html", "summary": "Growth hormone releasing peptide, second-generation. Stimulates GH and increases appetite.", "mechanism": "Ghrelin receptor agonist with cortisol and prolactin co-stimulation.", "evidence": "Pharmacokinetics well-characterized; less selective than Ipamorelin.", "common_dose": "100\u2013300 mcg 1\u20133\u00d7 daily subcutaneous", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "GHRP-6", "slug": "ghrp-6", "category": "Growth Hormone", "url": "https://rxcomparehub.com/peptides/ghrp-6.html", "summary": "First-generation GH releasing peptide. Strong appetite-stimulating effect.", "mechanism": "Ghrelin receptor agonist.", "evidence": "Pharmacokinetics well-characterized; superseded clinically by Ipamorelin.", "common_dose": "100\u2013300 mcg 1\u20133\u00d7 daily subcutaneous", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "DSIP (Delta Sleep-Inducing Peptide)", "slug": "dsip", "category": "Sleep", "url": "https://rxcomparehub.com/peptides/dsip.html", "summary": "Naturally-occurring peptide first isolated from the cerebral venous blood of sleeping rabbits. Used compounded for sleep regulation and stress.", "mechanism": "Modulates delta-wave sleep; influences hypothalamic-pituitary axis.", "evidence": "Limited human evidence; experimental.", "common_dose": "100\u2013500 mcg subcutaneous before sleep", "providers": [ "NexLife", "Defy Medical" ] }, { "name": "Cagrilintide", "slug": "cagrilintide", "category": "Weight Loss", "url": "https://rxcomparehub.com/peptides/cagrilintide.html", "summary": "Long-acting amylin analog under development by Novo Nordisk. Combined with semaglutide (CagriSema) for amplified weight loss. Recently used in functional medicine GLP-1 stacks.", "mechanism": "Amylin receptor agonist; slows gastric emptying, suppresses appetite via amylin receptors (distinct from GLP-1).", "evidence": "Phase 3 trials (REDEFINE program). Not yet FDA-approved.", "common_dose": "Experimental in compounded stacks; 0.25\u20132.4 mg weekly", "providers": [ "NexLife", "Defy Medical" ] } ] }